منابع مشابه
Reproductive toxicology. Diethylhexyl phthalate, juvenile exposure, mice.
Background: The objective of this study was to evaluate serum IGF-I levels in postmenopausal women with breast cancer treated primarily with raloxifene. Methods: Twenty-two postmenopausal patients with operable, stage I or II, estrogen receptorpositive carcinomas participated in this study. Following confirmation of diagnosis, the patients received 60 mg of raloxifene for 28 days prior to defin...
متن کاملJuvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists.
The Society of Toxicologic Pathology (STP) Education Committee and the STP Reproductive Special Interest Group held a North Carolina regional meeting entitled, "Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists" on March 13, 2015, at the National Institute of Environmental Health Sciences/National Toxicology Program in Research Triangle Park, North Carolina. The p...
متن کاملImaging MS in Toxicology: An Investigation of Juvenile Rat Nephrotoxicity Associated with Dabrafenib Administration
As part of an investigative nephrotoxicity study, kidney tissues from juvenile rats orally administered dabrafenib at different age intervals between postnatal day (PND) 7 to 35 were investigated by MALDI and LDI imaging mass spectrometry (IMS) to determine the chemical composition of tubular deposits. In the youngest age group (PND 7-13), MALDI IMS demonstrated that a dabrafenib carboxylic aci...
متن کاملA review of Novichok Toxicology
Introduction: Novichoks are considered as the fourth generation of chemical weapons and nerve agents (NA) category. NAs were produced and developed during the Cold War in the (former) Soviet :union:. Due to the confidentiality of the manufacturing process of these agents, there is little information about the properties of these compounds. Like other NA, novichoks are organophosphorus compounds...
متن کاملPharmacology and Toxicology of Leflunomide
Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2015
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623315595883